QUALITY CONTROL ASSESSMENT OF FOUR BRANDS OF TINIDAZOLE TABLETS MARKETED WITHIN KADUNA METROPOLIS, KADUNA-NIGERIA
DOI:
https://doi.org/10.56892/bima.v2i02.95Keywords:
Tinidazole tablets, Nitroimidazole, Quality Control, and Bioequivalence.Abstract
Introduction: Like most drugs, various brands of tinidazole tablets are available in Nigeria
and therapeutically equivalent products are being selected for various reasons. This study
aimed to investigate the quality control parameters of four commonly used tablet brands of
tinidazole in Kaduna, Nigeria with a view to ascertain the quality and interchangeability of
the different brands of the tablets. Four brands of tinidazole tablets sourced from the major
pharmacies within Kaduna metropolis were identified, assayed and evaluated for uniformity
of weight, friability, disintegration time, uniformity of dosage units and dissolution following
standard BP (2009) procedures. The IR spectra and melting points (125-128°C) analysis of
the four brands were within the normal compendium specified range. The brands passed the
uniformity of weight and friability tests.Additionally, the absolute drug content of tinidazole
in two of the four brands was however outside the specified range. Three (3) of the four (4)
brands passed the disintegration tests within the disintegration time frame of less than 15
minutes. The four brands of tinidazole tablets marketed in Kaduna city vary in quality and so
their use interchangeably should be carefully considered.
