PREPARATION AND CHARACTERIZATIONS OF HYDROXYAPATITE-SODIUM ALGINATE NANOCOMPOSITES FOR BIOMEDICAL APPLICATIONS
DOI:
https://doi.org/10.56892/bima.v2i01.58Keywords:
Nanocomposite, sodium alginate, hydroxyapatite, biomedical, FTIR, XRD, SEMAbstract
Polymer-inorganic nanocomposites are presently impacting diverse areas, specifically in
biomedical sciences. In this research, hydroxyapatite-sodium alginate has been prepared, and
characterized, with emphasis on the influence of sodium alginate on its characteristics. In situ
wet chemical precipitation method was used in the preparation. The prepared nanocomposite
was characterized with Fourier Transform Infrared spectroscopy (FTIR), Scanning Electron
Microscopy (SEM), with image analysis, and X-Ray Diffraction (XRD). The FTIR study
shows peaks characteristics of hydroxyapatite and confirmed formation of the nanocomposite
via chemical interaction between sodium alginate and hydroxyapatite. Image analysis shows
the nanocomposites to be of irregular morphologies which did not show significant change
with increasing sodium alginate addition, while particle size decreased with increase in
sodium alginate addition (359.46 nm to 109.98 nm).From the XRD data, both the crystallite
size and degree of crystallinity also decreased with increasing sodium alginate composition
(32.36 nm to 9.47 nm and 72.87% to 1.82% respectively), while the specific surface area and
microstrain increased with increasing sodium alginate composition (0.0041 to 0.0139 and
58.99 m2/g to 201.58 m2/g respectively). The results show that the formulation with 50%wt
of sodium alginate (HASA-50%wt), possess exceptional characteristics for biomedical
applications such as drug delivery.
