SYNTHESIS, CHARACTERIZATION, CYTOTOXICITY AND ANTIMCIROBIAL STUDIES OF METAL(II) COMPLEXES OF SCHIFF BASE DERIVED FROM 2- BENZOYLBENZOIC ACID AND 1,3-DIAMINOPROPANE

UMAR  SANI; AISHA S.  DAYYIB; SAMAILA  ABUBAKAR; DAILAMI S.  ADAM

SYNTHESIS, CHARACTERIZATION, CYTOTOXICITY AND ANTIMCIROBIAL STUDIES OF METAL(II) COMPLEXES OF SCHIFF BASE DERIVED FROM 2- BENZOYLBENZOIC ACID AND 1,3-DIAMINOPROPANE

Authors

UMAR SANI Department of Pure and Industrial Chemistry, College of Physical Sciences, Bayero University, PMB 3011 Kano.
AISHA S. DAYYIB Department of Pure and Industrial Chemistry, College of Physical Sciences, Bayero University, PMB 3011 Kano.
SAMAILA ABUBAKAR Department of Chemistry, Gombe State University, PMB 127 Gombe, Gombe State
DAILAMI S. ADAM Department of Chemistry, Federal University Lokoja, PMB 1154 Lokoja, Kogi State

Keywords:

Schiff base Metal complexes Spectroscopic study Antimicrobial activity Solubility Cytotoxicity activity

Abstract

Metal complexes of Ni(II), Cu(II) and Zn(II) with a Schiff base derived from 2-benzoylbenzoic
acid and 1,3-diaminopropan have been prepared and characterized. Infrared spectral studies
reveal that Schiff base behaves as a neutral tetradentate ligand and coordinates to the metal
ions via the two azomethine nitrogen and carboxylate oxygen. Molar conductance
measurement of (7.97 – 29.46) ohm-1 cm2 mol-1 indicates a non-electrolytic nature of all the
complexes. Solubility test showed that all complexes and Schiff base are soluble in DMSO and
methanol. Magnetic susceptibility and IR studies suggests tetrahedral structure for the
complexes while Job’s method of continues variation establish 1:1 metal to ligand ratio, on
which basis the coordination structures are proposed. The in vitro antibacterial and antifungal
activity showed that the complexes are more active than the Schiff base. Moreover, the
cytotoxicity analysis indicates that the tested compounds possess low toxicity.

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Published

2021-06-13

How to Cite

SANI, U., DAYYIB, A. S. ., ABUBAKAR, S. ., & ADAM, D. S. . (2021). SYNTHESIS, CHARACTERIZATION, CYTOTOXICITY AND ANTIMCIROBIAL STUDIES OF METAL(II) COMPLEXES OF SCHIFF BASE DERIVED FROM 2- BENZOYLBENZOIC ACID AND 1,3-DIAMINOPROPANE. BIMA JOURNAL OF SCIENCE AND TECHNOLOGY (2536-6041), 5(01), 225-237. Retrieved from https://journals.gjbeacademia.com/index.php/bimajst/article/view/279