EFFECT OF SYNTHETIC ROUTE OF HYDROXYAPATITE-SODIUM ALGINATE COMPOSITE ON LOADING AND RELEASE PROFILES OF ANTICANCER AGENTS - DOXORUBICIN AND METHOTREXATE
Keywords:
alginate, composite, doxorubicin, Drug loading, methotrexate, release profiles.Abstract
Processing parameters and mode of formation significantly influence the properties and
interfacial characteristics of composites. Drug loading and release profiles of two
hydroxyapatite-sodium alginates prepared through different routes were compared using two
anticancer drugs – Doxorubicin (DOX) and Methotrexate (MTX). Drug loading was carried
out at neutral pH, while in vitro drug release study was carried out in synthetic body fluid (SBF)
at pH 7.4 and 37 oC. The major peaks from the FTIR spectra show that the two synthetic routes
yielded composites with similar functional groups. The second synthetic route (2HASA)
presented higher DOX loading efficiency than the first synthetic route (HASA), while for MTX
2HASA loaded higher only at lower sodium alginate contents (HASA-5%and HASA 20%).
The release profiles for all the compared pairs have similarity factor (f2) above 50, indicating
that DOX release from composites prepared following the two synthetic methods have similar
release profiles. The drug loading efficiency showed that the second synthetic route (2HASA)
loaded higher than the first synthetic route (HASA), while the release profiles for the two
synthetic routes are similar.
